Assay Detail
Binding
CHEMBL663602
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Cyclin-dependent kinase 5-p35nck5a
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Structural basis for the synthesis of indirubins as potent and selective inhibitors of glycogen synthase kinase-3 and cyclin-dependent kinases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 38 | 5.95 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL366414 | — | — | 1 | 7.22 |
| CHEMBL409450 | 6BIO | — | 1 | 7.08 |
| CHEMBL173040 | — | — | 1 | 7.00 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | — | 1 | 7.00 |
| CHEMBL253769 | INDIRUBIN 1 | — | 1 | 7.00 |
| CHEMBL175155 | — | — | 1 | 6.89 |
| CHEMBL170640 | — | — | 1 | 6.82 |
| CHEMBL174292 | — | — | 1 | 6.82 |
| CHEMBL174068 | — | — | 1 | 6.70 |
| CHEMBL177146 | — | — | 1 | 6.52 |
| CHEMBL352781 | — | — | 1 | 6.52 |
| CHEMBL368954 | — | — | 1 | 6.40 |
| CHEMBL170138 | — | — | 1 | 6.40 |
| CHEMBL369823 | — | — | 1 | 6.38 |
| CHEMBL176896 | — | — | 1 | 6.16 |
| CHEMBL172540 | — | — | 1 | 6.00 |
| CHEMBL354042 | — | — | 1 | 5.92 |
| CHEMBL353554 | — | — | 1 | 5.89 |
| CHEMBL441109 | — | — | 1 | 5.89 |
| CHEMBL354276 | — | — | 1 | 5.66 |
| CHEMBL430226 | 6-BROMOINDIRUBIN-3'-ACETOXIME | — | 1 | 5.62 |
| CHEMBL175053 | — | — | 1 | 5.62 |
| CHEMBL174343 | — | — | 1 | 5.28 |
| CHEMBL176306 | — | — | 1 | 5.00 |
| CHEMBL1276127 | INDIRUBIN | 2.0 | 1 | 5.00 |
| CHEMBL174612 | — | — | 1 | 4.52 |
| CHEMBL172547 | — | — | 1 | 4.51 |
| CHEMBL176904 | — | — | 1 | 4.28 |
| CHEMBL173178 | — | — | 1 | 4.22 |
| CHEMBL367664 | — | — | 1 | 4.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL366414 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL409450 | 6BIO | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL126077 | INDIRUBIN-3-MONOXIME | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL253769 | INDIRUBIN 1 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL173040 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL175155 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL170640 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL174292 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL174068 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL177146 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL352781 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL368954 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL170138 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL369823 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL176896 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL172540 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL354042 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL353554 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL441109 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL354276 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL175053 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL430226 | 6-BROMOINDIRUBIN-3'-ACETOXIME | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL174343 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL176306 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1276127 | INDIRUBIN | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL174612 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL172547 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL176904 | — | IC50 | = | 53000.0 | nM | 4.28 |
| CHEMBL367664 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL173178 | — | IC50 | = | 60000.0 | nM | 4.22 |
| CHEMBL366438 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL174473 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL367687 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL369220 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL368112 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL170347 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL173171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL435707 | — | IC50 | > | 100000.0 | nM | - |