Assay Detail

CHEMBL663603

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Binding

Inhibition of Cyclin-dependent kinase 5-p35nck5a

ChEMBL ↗

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Target

Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗

Open DB target context

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Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Cyclin-dependent kinase 5/CDK5 activator 1

CHEMBL1907600

Anchored from Assay target.

Protein identity Cyclin-dependent kinase 5/CDK5 activator 1

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Confidence	6 — Multiple protein complex / RNA
Curated By	Autocuration

Target

Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

3-Aminopyrazole inhibitors of CDK2/cyclin A as antitumor agents. 1. Lead finding.

Pevarello P, Brasca MG, Amici R, Orsini P, Traquandi G, Corti L, Piutti C, Sansonna P, Villa M, Pierce BS, Pulici M, Giordano P, Martina K, Fritzen EL, Nugent RA, Casale E, Cameron A, Ciomei M, Roletto F, Isacchi A, Fogliatto G, Pesenti E, Pastori W, Marsiglio A, Leach KL, Clare PM, Fiorentini F, Varasi M, Vulpetti A, Warpehoski MA.
J Med Chem (2004) 47 : 3367 -3380
PubMed 15189033 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	6.94	6.94

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL115220	—	—	1	6.94

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL115220	—	IC50	=	114.0	nM	6.94