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Assay Detail

CHEMBL663616

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Binding
Inhibitory activity against cyclin-dependent kinase 5/p25
ChEMBL ↗
70
Total Activities
70
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 6 — Multiple protein complex / RNA
Curated By Autocuration

Target

Cyclin-dependent kinase 5/CDK5 activator 1 (CHEMBL1907600) ↗
Type PROTEIN COMPLEX
Organism Homo sapiens

Publication

Evaluation and comparison of 3D-QSAR CoMSIA models for CDK1, CDK5, and GSK-3 inhibition by paullones.
Kunick C, Lauenroth K, Wieking K, Xie X, Schultz C, Gussio R, Zaharevitz D, Leost M, Meijer L, Weber A, Jørgensen FS, Lemcke T.
J Med Chem (2004) 47 : 22 -36
PubMed 14695817 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 70 5.66 7.68

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL331190 — — 1 7.68
CHEMBL121492 — — 1 7.48
CHEMBL299756 PAULLONE 2 — 1 7.36
CHEMBL325654 — — 1 7.22
CHEMBL325403 — — 1 7.16
CHEMBL119963 — — 1 7.00
CHEMBL333006 — — 1 6.92
CHEMBL118162 — — 1 6.50
CHEMBL333894 — — 1 6.38
CHEMBL328194 — — 1 6.37
CHEMBL319373 — — 1 6.30
CHEMBL329505 — — 1 6.22
CHEMBL116545 — — 1 6.20
CHEMBL98153 — — 1 6.10
CHEMBL331000 — — 1 6.08
CHEMBL332359 — — 1 6.00
CHEMBL99037 — — 1 5.89
CHEMBL318911 — — 1 5.77
CHEMBL120497 — — 1 5.77
CHEMBL121543 — — 1 5.70
CHEMBL95827 — — 1 5.68
CHEMBL334084 — — 1 5.66
CHEMBL98554 — — 1 5.57
CHEMBL318471 — — 1 5.54
CHEMBL100309 — — 1 5.52
CHEMBL331783 — — 1 5.48
CHEMBL323657 — — 1 5.40
CHEMBL334031 — — 1 5.30
CHEMBL120030 — — 1 5.28
CHEMBL431634 — — 1 5.27

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL331190 — IC50 = 20.99 nM 7.68
CHEMBL121492 — IC50 = 33.04 nM 7.48
CHEMBL299756 PAULLONE 2 IC50 = 43.95 nM 7.36
CHEMBL325654 — IC50 = 59.98 nM 7.22
CHEMBL325403 — IC50 = 69.98 nM 7.16
CHEMBL119963 — IC50 = 100.0 nM 7.00
CHEMBL333006 — IC50 = 119.95 nM 6.92
CHEMBL118162 — IC50 = 319.89 nM 6.50
CHEMBL333894 — IC50 = 419.76 nM 6.38
CHEMBL328194 — IC50 = 429.54 nM 6.37
CHEMBL319373 — IC50 = 500.03 nM 6.30
CHEMBL329505 — IC50 = 599.79 nM 6.22
CHEMBL116545 — IC50 = 629.51 nM 6.20
CHEMBL98153 — IC50 = 799.83 nM 6.10
CHEMBL331000 — IC50 = 829.85 nM 6.08
CHEMBL332359 — IC50 = 1000.0 nM 6.00
CHEMBL99037 — IC50 = 1300.17 nM 5.89
CHEMBL318911 — IC50 = 1698.24 nM 5.77
CHEMBL120497 — IC50 = 1698.24 nM 5.77
CHEMBL121543 — IC50 = 1999.86 nM 5.70
CHEMBL95827 — IC50 = 2098.94 nM 5.68
CHEMBL334084 — IC50 = 2197.86 nM 5.66
CHEMBL98554 — IC50 = 2697.74 nM 5.57
CHEMBL318471 — IC50 = 2897.34 nM 5.54
CHEMBL100309 — IC50 = 2999.16 nM 5.52
CHEMBL331783 — IC50 = 3303.7 nM 5.48
CHEMBL323657 — IC50 = 3999.45 nM 5.40
CHEMBL334031 — IC50 = 5000.35 nM 5.30
CHEMBL120030 — IC50 = 5296.63 nM 5.28
CHEMBL431634 — IC50 = 5395.11 nM 5.27
CHEMBL120941 — IC50 = 5495.41 nM 5.26
CHEMBL317964 — IC50 = 6295.06 nM 5.20
CHEMBL121957 — IC50 = 6998.42 nM 5.16
CHEMBL116832 — IC50 = 7396.05 nM 5.13
CHEMBL329063 — IC50 = 7998.34 nM 5.10
CHEMBL52551 — IC50 = 7998.34 nM 5.10
CHEMBL120664 — IC50 = 8298.51 nM 5.08
CHEMBL98501 — IC50 = 8994.98 nM 5.05
CHEMBL419054 — IC50 = 9506.05 nM 5.02
CHEMBL430574 PAULLONE IC50 = 10092.53 nM 5.00
CHEMBL98360 — IC50 = 10000.0 nM 5.00
CHEMBL120078 — IC50 = 13001.7 nM 4.89
CHEMBL121958 — IC50 = 14996.85 nM 4.82
CHEMBL317150 — IC50 = 23014.42 nM 4.64
CHEMBL333066 — IC50 = 29991.63 nM 4.52
CHEMBL120355 — IC50 = 29991.63 nM 4.52
CHEMBL119989 — IC50 = 33962.53 nM 4.47
CHEMBL118406 — IC50 = 39994.47 nM 4.40
CHEMBL331722 — IC50 = 41975.9 nM 4.38
CHEMBL99779 PAULLONE IC50 = 269773.94 nM -