Assay Detail
Binding
CHEMBL663660
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In vitro IC50 value by measuring the inhibition of deoxyhypusine synthase.
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 51 | 5.20 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL229457 | — | — | 1 | 7.52 |
| CHEMBL103941 | — | — | 1 | 7.10 |
| CHEMBL103613 | — | — | 1 | 6.80 |
| CHEMBL102939 | — | — | 1 | 6.52 |
| CHEMBL101419 | — | — | 1 | 6.26 |
| CHEMBL105951 | — | — | 1 | 6.16 |
| CHEMBL280222 | — | — | 1 | 5.92 |
| CHEMBL321347 | — | — | 1 | 5.72 |
| CHEMBL102329 | — | — | 1 | 5.50 |
| CHEMBL102487 | — | — | 1 | 5.47 |
| CHEMBL102276 | IMINOCTADIENE | — | 1 | 5.46 |
| CHEMBL101996 | — | — | 1 | 5.17 |
| CHEMBL105647 | — | — | 1 | 5.10 |
| CHEMBL102323 | — | — | 1 | 5.05 |
| CHEMBL29910 | — | — | 1 | 4.89 |
| CHEMBL105338 | — | — | 1 | 4.89 |
| CHEMBL73634 | — | — | 1 | 4.79 |
| CHEMBL106009 | — | — | 1 | 4.68 |
| CHEMBL103489 | — | — | 1 | 4.54 |
| CHEMBL102951 | — | — | 1 | 4.42 |
| CHEMBL317697 | — | — | 1 | 4.40 |
| CHEMBL28743 | NORSPERMIDINE | — | 1 | 4.39 |
| CHEMBL106117 | — | — | 1 | 4.32 |
| CHEMBL322423 | — | — | 1 | 4.20 |
| CHEMBL103266 | — | — | 1 | 4.13 |
| CHEMBL29299 | — | — | 1 | 4.08 |
| CHEMBL102924 | — | — | 1 | 4.02 |
| CHEMBL101802 | — | — | 1 | 4.00 |
| CHEMBL102800 | — | — | 1 | - |
| CHEMBL102267 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL229457 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL103941 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL103613 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL102939 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL101419 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL105951 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL280222 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL321347 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL102329 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL102487 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL102276 | IMINOCTADIENE | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL101996 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL105647 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL102323 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL105338 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL29910 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL73634 | — | IC50 | = | 16100.0 | nM | 4.79 |
| CHEMBL106009 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL103489 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL102951 | — | IC50 | = | 38000.0 | nM | 4.42 |
| CHEMBL317697 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL28743 | NORSPERMIDINE | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL106117 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL322423 | — | IC50 | = | 63000.0 | nM | 4.20 |
| CHEMBL103266 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL29299 | — | IC50 | = | 83000.0 | nM | 4.08 |
| CHEMBL102924 | — | IC50 | = | 96000.0 | nM | 4.02 |
| CHEMBL101802 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL35633 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL102740 | ARCAINE | IC50 | = | 179000.0 | nM | - |
| CHEMBL28866 | — | IC50 | = | 235000.0 | nM | - |
| CHEMBL104907 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL36119 | — | IC50 | = | 556000.0 | nM | - |
| CHEMBL105749 | — | IC50 | = | 385000.0 | nM | - |
| CHEMBL75214 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL105668 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL102933 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL103031 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL103880 | — | IC50 | = | 275000.0 | nM | - |
| CHEMBL103897 | — | IC50 | = | 132000.0 | nM | - |
| CHEMBL104233 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL58343 | AGMATINE | IC50 | = | 156000.0 | nM | - |
| CHEMBL102640 | — | IC50 | = | 780000.0 | nM | - |
| CHEMBL103023 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL102715 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL105574 | — | IC50 | = | 120000.0 | nM | - |
| CHEMBL318516 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL105316 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL102267 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL102800 | — | IC50 | > | 1000000.0 | nM | - |