Assay Detail
Binding
CHEMBL663690
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Apparent dissociation constant at pH 6.6 for Chicken dihydrofolate reductase in the absence of cofactor NADPH
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Lacticaseibacillus casei |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Structure-activity relationships and pH dependence of binding of 8-alkyl-N5-deazapterins to dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 16 | 4.92 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL336628 | — | — | 1 | 5.60 |
| CHEMBL135936 | — | — | 1 | 5.48 |
| CHEMBL135581 | — | — | 1 | 5.47 |
| CHEMBL135937 | — | — | 1 | 5.46 |
| CHEMBL134613 | — | — | 1 | 5.43 |
| CHEMBL340269 | — | — | 1 | 5.12 |
| CHEMBL341200 | — | — | 1 | 4.96 |
| CHEMBL436184 | — | — | 1 | 4.80 |
| CHEMBL133360 | — | — | 1 | 4.80 |
| CHEMBL135811 | — | — | 1 | 4.75 |
| CHEMBL424647 | — | — | 1 | 4.70 |
| CHEMBL134466 | — | — | 1 | 4.42 |
| CHEMBL136042 | — | — | 1 | 4.36 |
| CHEMBL135622 | — | — | 1 | 4.24 |
| CHEMBL134383 | — | — | 1 | 4.22 |
| CHEMBL135905 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL336628 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL135936 | — | Kd | = | 3300.0 | nM | 5.48 |
| CHEMBL135581 | — | Kd | = | 3400.0 | nM | 5.47 |
| CHEMBL135937 | — | Kd | = | 3500.0 | nM | 5.46 |
| CHEMBL134613 | — | Kd | = | 3700.0 | nM | 5.43 |
| CHEMBL340269 | — | Kd | = | 7500.0 | nM | 5.12 |
| CHEMBL341200 | — | Kd | = | 11000.0 | nM | 4.96 |
| CHEMBL436184 | — | Kd | = | 16000.0 | nM | 4.80 |
| CHEMBL133360 | — | Kd | = | 16000.0 | nM | 4.80 |
| CHEMBL135811 | — | Kd | = | 18000.0 | nM | 4.75 |
| CHEMBL424647 | — | Kd | = | 20000.0 | nM | 4.70 |
| CHEMBL134466 | — | Kd | = | 38000.0 | nM | 4.42 |
| CHEMBL136042 | — | Kd | = | 44000.0 | nM | 4.36 |
| CHEMBL135622 | — | Kd | = | 58000.0 | nM | 4.24 |
| CHEMBL134383 | — | Kd | = | 60000.0 | nM | 4.22 |
| CHEMBL135905 | — | Kd | = | 138000.0 | nM | - |