Assay Detail
Functional
CHEMBL663797
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of the drug to reduce cell number to 50% of controls in D3F cell line
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | D3F |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Dicationic bis(9-methylphenazine-1-carboxamides): relationships between biological activity and linker chain structure for a series of potent topoisomerase targeted anticancer drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.36 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL30232 | — | — | 1 | 8.54 |
| CHEMBL30424 | — | — | 1 | 8.36 |
| CHEMBL31879 | — | — | 1 | 8.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL30232 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL30424 | — | IC50 | = | 4.4 | nM | 8.36 |
| CHEMBL31879 | — | IC50 | = | 6.5 | nM | 8.19 |