Assay Detail
Binding
CHEMBL663871
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Inhibition constant against Bacillus subtilis DNA topoisomerase III (wild type).
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacillus subtilis |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
DNA topoisomerase 3 (CHEMBL4320) ↗| Type | SINGLE PROTEIN |
| Organism | Bacillus subtilis (strain 168) |
Publication
Quantitative structure-activity relationships of 6-anilinouracils as inhibitors of Bacillus subtilis DNA polymerase III.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 37 | 5.25 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53002 | — | — | 1 | 6.72 |
| CHEMBL55032 | — | — | 1 | 6.58 |
| CHEMBL56014 | — | — | 1 | 6.42 |
| CHEMBL54950 | — | — | 1 | 6.38 |
| CHEMBL55145 | — | — | 1 | 6.20 |
| CHEMBL54782 | — | — | 1 | 6.04 |
| CHEMBL52034 | — | — | 1 | 6.03 |
| CHEMBL53413 | — | — | 1 | 6.00 |
| CHEMBL51750 | — | — | 1 | 5.54 |
| CHEMBL300465 | — | — | 1 | 5.33 |
| CHEMBL441976 | — | — | 1 | 5.12 |
| CHEMBL291461 | — | — | 1 | 4.99 |
| CHEMBL54814 | — | — | 1 | 4.77 |
| CHEMBL57397 | — | — | 1 | 4.76 |
| CHEMBL54371 | — | — | 1 | 4.72 |
| CHEMBL54530 | — | — | 1 | 4.72 |
| CHEMBL51694 | — | — | 1 | 4.60 |
| CHEMBL54949 | — | — | 1 | 4.60 |
| CHEMBL293964 | — | — | 1 | 4.50 |
| CHEMBL52018 | — | — | 1 | 4.37 |
| CHEMBL299529 | — | — | 1 | 4.18 |
| CHEMBL54490 | — | — | 1 | 4.11 |
| CHEMBL54632 | — | — | 1 | 4.01 |
| CHEMBL298952 | — | — | 1 | - |
| CHEMBL299172 | — | — | 1 | - |
| CHEMBL299412 | — | — | 1 | - |
| CHEMBL53228 | — | — | 1 | - |
| CHEMBL53209 | — | — | 1 | - |
| CHEMBL298559 | — | — | 1 | - |
| CHEMBL294156 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53002 | — | Ki | = | 190.11 | nM | 6.72 |
| CHEMBL55032 | — | Ki | = | 260.02 | nM | 6.58 |
| CHEMBL56014 | — | Ki | = | 380.19 | nM | 6.42 |
| CHEMBL54950 | — | Ki | = | 419.76 | nM | 6.38 |
| CHEMBL55145 | — | Ki | = | 629.51 | nM | 6.20 |
| CHEMBL54782 | — | Ki | = | 920.45 | nM | 6.04 |
| CHEMBL52034 | — | Ki | = | 928.97 | nM | 6.03 |
| CHEMBL53413 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL51750 | — | Ki | = | 2897.34 | nM | 5.54 |
| CHEMBL300465 | — | Ki | = | 4698.94 | nM | 5.33 |
| CHEMBL441976 | — | Ki | = | 7603.26 | nM | 5.12 |
| CHEMBL291461 | — | Ki | = | 10303.86 | nM | 4.99 |
| CHEMBL54814 | — | Ki | = | 16982.44 | nM | 4.77 |
| CHEMBL57397 | — | Ki | = | 17498.47 | nM | 4.76 |
| CHEMBL54530 | — | Ki | = | 19010.78 | nM | 4.72 |
| CHEMBL54371 | — | Ki | = | 19010.78 | nM | 4.72 |
| CHEMBL51694 | — | Ki | = | 25003.45 | nM | 4.60 |
| CHEMBL54949 | — | Ki | = | 25003.45 | nM | 4.60 |
| CHEMBL293964 | — | Ki | = | 31622.78 | nM | 4.50 |
| CHEMBL52018 | — | Ki | = | 42756.29 | nM | 4.37 |
| CHEMBL299529 | — | Ki | = | 65765.78 | nM | 4.18 |
| CHEMBL54490 | — | Ki | = | 78523.56 | nM | 4.11 |
| CHEMBL54632 | — | Ki | = | 97949.0 | nM | 4.01 |
| CHEMBL53109 | — | Ki | = | 691830.97 | nM | - |
| CHEMBL54362 | — | Ki | = | 4954501.91 | nM | - |
| CHEMBL53162 | — | Ki | = | 121898.96 | nM | - |
| CHEMBL54861 | — | Ki | = | 119949.93 | nM | - |
| CHEMBL299948 | — | Ki | = | 641209.58 | nM | - |
| CHEMBL433486 | — | Ki | = | 451855.94 | nM | - |
| CHEMBL54419 | — | Ki | = | 341979.44 | nM | - |
| CHEMBL294156 | — | Ki | = | 100925.29 | nM | - |
| CHEMBL298559 | — | Ki | = | 3198895.11 | nM | - |
| CHEMBL53209 | — | Ki | = | 695024.32 | nM | - |
| CHEMBL53228 | — | Ki | = | 1770108.96 | nM | - |
| CHEMBL299412 | — | Ki | = | 464515.28 | nM | - |
| CHEMBL299172 | — | Ki | = | 413047.5 | nM | - |
| CHEMBL298952 | — | Ki | = | 464515.28 | nM | - |