Assay Detail
Binding
CHEMBL664029
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human dipeptidyl peptidase IV (DPP IV) obtained from human colonic carcinoma cells
88
Total Activities
88
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 88 | 6.82 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307636 | — | — | 1 | 8.70 |
| CHEMBL96666 | — | — | 1 | 8.70 |
| CHEMBL319080 | — | — | 1 | 8.52 |
| CHEMBL3084811 | — | — | 1 | 8.46 |
| CHEMBL3084815 | — | — | 1 | 8.30 |
| CHEMBL3084812 | — | — | 1 | 8.15 |
| CHEMBL3084816 | — | — | 1 | 8.15 |
| CHEMBL77539 | — | — | 1 | 8.10 |
| CHEMBL3084820 | — | — | 1 | 8.00 |
| CHEMBL96892 | — | — | 1 | 7.89 |
| CHEMBL3084821 | — | — | 1 | 7.85 |
| CHEMBL330373 | — | — | 1 | 7.82 |
| CHEMBL96459 | — | — | 1 | 7.80 |
| CHEMBL3084814 | — | — | 1 | 7.77 |
| CHEMBL3084819 | — | — | 1 | 7.75 |
| CHEMBL3084825 | — | — | 1 | 7.66 |
| CHEMBL77538 | — | — | 1 | 7.66 |
| CHEMBL319798 | — | — | 1 | 7.64 |
| CHEMBL96908 | — | — | 1 | 7.62 |
| CHEMBL95088 | — | — | 1 | 7.58 |
| CHEMBL327166 | — | — | 1 | 7.54 |
| CHEMBL92711 | — | — | 1 | 7.48 |
| CHEMBL96937 | — | — | 1 | 7.46 |
| CHEMBL93354 | — | — | 1 | 7.44 |
| CHEMBL96593 | — | — | 1 | 7.28 |
| CHEMBL95089 | — | — | 1 | 7.27 |
| CHEMBL3084823 | — | — | 1 | 7.21 |
| CHEMBL323130 | — | — | 1 | 7.20 |
| CHEMBL431425 | — | — | 1 | 7.19 |
| CHEMBL3084817 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307636 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL96666 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL319080 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL3084811 | — | IC50 | = | 3.5 | nM | 8.46 |
| CHEMBL3084815 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL3084812 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL3084816 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL77539 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL3084820 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL96892 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL3084821 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL330373 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL96459 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3084814 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL3084819 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL3084825 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL77538 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL319798 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL96908 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL95088 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL327166 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL92711 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL96937 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL93354 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL96593 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL95089 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL3084823 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL323130 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL431425 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3084817 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3084822 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL94312 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL330717 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL318775 | — | IC50 | = | 102.0 | nM | 6.99 |
| CHEMBL92028 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL94908 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL94630 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL328994 | — | IC50 | = | 133.0 | nM | 6.88 |
| CHEMBL3084824 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL329909 | — | IC50 | = | 163.0 | nM | 6.79 |
| CHEMBL3084818 | — | IC50 | = | 183.0 | nM | 6.74 |
| CHEMBL96748 | — | IC50 | = | 192.0 | nM | 6.72 |
| CHEMBL323129 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL328794 | — | IC50 | = | 228.0 | nM | 6.64 |
| CHEMBL96071 | — | IC50 | = | 242.0 | nM | 6.62 |
| CHEMBL92710 | — | IC50 | = | 256.0 | nM | 6.59 |
| CHEMBL317787 | — | IC50 | = | 261.0 | nM | 6.58 |
| CHEMBL96160 | — | IC50 | = | 266.0 | nM | 6.58 |
| CHEMBL96491 | — | IC50 | = | 282.0 | nM | 6.55 |
| CHEMBL94147 | — | IC50 | = | 291.0 | nM | 6.54 |