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Assay Detail

CHEMBL664064

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Functional
Inhibition of dihydrosterculate synthesis in Crithidia fasciculata.
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Crithidia fasciculata
Confidence 1 — Organism
Curated By Intermediate

Target

Crithidia fasciculata (CHEMBL612650)
Type ORGANISM
Organism Crithidia fasciculata

Publication

Effects of sulfur-containing analogues of stearic acid on growth and fatty acid biosynthesis in the protozoan Crithidia fasciculata.
Rahman MD, Ziering DL, Mannarelli SJ, Swartz KL, Huang DS, Pascal RA.
J Med Chem (1988) 31 : 1656 -1659
PubMed 3398003 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 6 5.57 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL44758 1 6.40
CHEMBL45430 1 6.05
CHEMBL46569 1 5.52
CHEMBL46427 1 5.40
CHEMBL416075 1 5.10
CHEMBL42811 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL44758 IC50 = 400.0 nM 6.40
CHEMBL45430 IC50 = 900.0 nM 6.05
CHEMBL46569 IC50 = 3000.0 nM 5.52
CHEMBL46427 IC50 = 4000.0 nM 5.40
CHEMBL416075 IC50 = 8000.0 nM 5.10
CHEMBL42811 IC50 = 12000.0 nM 4.92