Assay Detail
Binding
CHEMBL664073
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Inhibition of cruzain, the major cysteine protease from Trypanosoma cruzi
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
CoMFA and HQSAR of acylhydrazide cruzain inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.19 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL39253 | — | — | 1 | 6.70 |
| CHEMBL39814 | — | — | 1 | 6.30 |
| CHEMBL39161 | — | — | 1 | 6.22 |
| CHEMBL416237 | — | — | 1 | 5.30 |
| CHEMBL39255 | — | — | 1 | 5.22 |
| CHEMBL38981 | — | — | 1 | 5.22 |
| CHEMBL289374 | — | — | 1 | 5.22 |
| CHEMBL40119 | — | — | 1 | 5.00 |
| CHEMBL40165 | — | — | 1 | 5.00 |
| CHEMBL39723 | — | — | 1 | 4.79 |
| CHEMBL289164 | — | — | 1 | 4.70 |
| CHEMBL40503 | — | — | 1 | 4.52 |
| CHEMBL289764 | — | — | 1 | 4.52 |
| CHEMBL38462 | — | — | 1 | 4.00 |
| CHEMBL37464 | — | — | 1 | - |
| CHEMBL285167 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL39253 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL39814 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL39161 | — | IC50 | = | 602.56 | nM | 6.22 |
| CHEMBL416237 | — | IC50 | = | 5011.87 | nM | 5.30 |
| CHEMBL39255 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL38981 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL289374 | — | IC50 | = | 6025.6 | nM | 5.22 |
| CHEMBL40119 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL40165 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL39723 | — | IC50 | = | 16218.1 | nM | 4.79 |
| CHEMBL289164 | — | IC50 | = | 19952.62 | nM | 4.70 |
| CHEMBL40503 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL289764 | — | IC50 | = | 30199.52 | nM | 4.52 |
| CHEMBL38462 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL37464 | — | IC50 | = | 331131.12 | nM | - |
| CHEMBL285167 | — | IC50 | = | 165958.69 | nM | - |