Assay Detail
Binding
CHEMBL664074
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Inhibition of cruzain from Trypanosoma cruzi
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.42 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL88734 | — | — | 1 | 7.22 |
| CHEMBL326220 | — | — | 1 | 5.30 |
| CHEMBL108700 | — | — | 1 | 5.30 |
| CHEMBL323975 | — | — | 1 | 5.30 |
| CHEMBL108101 | — | — | 1 | 5.30 |
| CHEMBL109619 | — | — | 1 | 5.30 |
| CHEMBL108035 | — | — | 1 | 5.10 |
| CHEMBL108865 | — | — | 1 | 5.00 |
| CHEMBL109893 | — | — | 1 | 5.00 |
| CHEMBL108077 | — | — | 1 | - |
| CHEMBL107612 | — | — | 1 | - |
| CHEMBL416771 | — | — | 1 | - |
| CHEMBL111632 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL88734 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL326220 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL108700 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL323975 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL108101 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL109619 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL108035 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL108865 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL109893 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL108077 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL107612 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL416771 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL111632 | — | IC50 | > | 20000.0 | nM | - |