Assay Detail
Binding
CHEMBL664077
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vivo ability to inhibit cyclooxygenase-2 enzyme in human whole blood was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Blood |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of 5,6-diarylimidazo[2.1-b]thiazole as selective COX-2 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.72 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL148976 | — | — | 1 | 6.40 |
| CHEMBL146742 | — | — | 1 | 6.05 |
| CHEMBL423576 | — | — | 1 | 5.66 |
| CHEMBL358609 | — | — | 1 | 4.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL148976 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL146742 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL423576 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL358609 | — | IC50 | = | 17500.0 | nM | 4.76 |