Assay Detail
Binding
CHEMBL664079
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Inhibition of PGE-2 production in CHO cells expressing human COX-2.
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | CHO |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 7.05 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 8.70 |
| CHEMBL322703 | — | — | 1 | 7.70 |
| CHEMBL320585 | — | — | 1 | 7.70 |
| CHEMBL108512 | — | — | 1 | 7.70 |
| CHEMBL122 | ROFECOXIB | 4.0 | 1 | 7.70 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.58 |
| CHEMBL322276 | — | — | 1 | 7.52 |
| CHEMBL108917 | — | — | 1 | 7.52 |
| CHEMBL107706 | — | — | 1 | 7.40 |
| CHEMBL110824 | — | — | 1 | 7.40 |
| CHEMBL322807 | — | — | 1 | 7.05 |
| CHEMBL110822 | — | — | 1 | 6.92 |
| CHEMBL320111 | — | — | 1 | 6.82 |
| CHEMBL110514 | — | — | 1 | 6.58 |
| CHEMBL106255 | — | — | 1 | 6.57 |
| CHEMBL321597 | — | — | 1 | 6.48 |
| CHEMBL108857 | — | — | 1 | 6.46 |
| CHEMBL320273 | — | — | 1 | 6.26 |
| CHEMBL326254 | — | — | 1 | 6.21 |
| CHEMBL323267 | — | — | 1 | 6.17 |
| CHEMBL319446 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL118 | CELECOXIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL322703 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL320585 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL108512 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL322276 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL108917 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL107706 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL110824 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL322807 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL110822 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL320111 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL110514 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL106255 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL321597 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL108857 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL320273 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL326254 | — | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL323267 | — | IC50 | = | 670.0 | nM | 6.17 |
| CHEMBL319446 | — | IC50 | = | 2900.0 | nM | 5.54 |