Assay Detail
Binding
CHEMBL664186
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Inhibitory activity against DHFR (Dihydrofolate reductase) from Pneumocystis carinii.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Structure-based design of selective inhibitors of dihydrofolate reductase: synthesis and antiparasitic activity of 2, 4-diaminopteridine analogues with a bridged diarylamine side chain.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 6.32 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL144839 | — | — | 1 | 7.38 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL423200 | — | — | 1 | 7.00 |
| CHEMBL144200 | — | — | 1 | 6.92 |
| CHEMBL301769 | — | — | 1 | 6.68 |
| CHEMBL342086 | — | — | 1 | 5.85 |
| CHEMBL423381 | — | — | 1 | 5.47 |
| CHEMBL424113 | — | — | 1 | 5.31 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL144839 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL423200 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL144200 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL301769 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL342086 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL423381 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL424113 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |