Assay Detail
Binding
CHEMBL664193
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Binding affinity was measured on rat Corticotropin releasing factor receptor 1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL4649) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.33 | 7.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL166162 | — | — | 1 | 7.42 |
| CHEMBL167264 | — | — | 1 | 7.34 |
| CHEMBL168568 | — | — | 1 | 7.02 |
| CHEMBL166102 | — | — | 1 | 6.73 |
| CHEMBL353075 | — | — | 1 | 5.96 |
| CHEMBL168764 | — | — | 1 | 5.48 |
| CHEMBL167217 | — | — | 1 | 5.44 |
| CHEMBL444577 | — | — | 1 | 5.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL166162 | — | Ki | = | 38.0 | nM | 7.42 |
| CHEMBL167264 | — | Ki | = | 46.0 | nM | 7.34 |
| CHEMBL168568 | — | Ki | = | 96.0 | nM | 7.02 |
| CHEMBL166102 | — | Ki | = | 187.0 | nM | 6.73 |
| CHEMBL353075 | — | Ki | = | 1099.0 | nM | 5.96 |
| CHEMBL168764 | — | Ki | = | 3301.0 | nM | 5.48 |
| CHEMBL167217 | — | Ki | = | 3655.0 | nM | 5.44 |
| CHEMBL444577 | — | Ki | = | 5700.0 | nM | 5.24 |