Assay Detail
Binding
CHEMBL664277
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Displacement of [3H]pentagastrin from Cholecystokinin receptor of mouse cerebral cortex
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Expert |
Publication
Synthesis and binding affinities of analogues of cholecystokinin-(30-33) as probes for central nervous system cholecystokinin receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 6.51 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64605 | — | — | 1 | 8.74 |
| CHEMBL415630 | — | — | 1 | 8.70 |
| CHEMBL1121 | SINCALIDE | 4.0 | 2 | 8.52 |
| CHEMBL120632 | TETRAGASTRIN | -1.0 | 1 | 8.52 |
| CHEMBL163010 | — | — | 1 | 5.80 |
| CHEMBL2371390 | — | — | 1 | 4.96 |
| CHEMBL352674 | — | — | 1 | 4.62 |
| CHEMBL352070 | — | — | 1 | 4.35 |
| CHEMBL32301 | — | — | 1 | 4.12 |
| CHEMBL163210 | — | — | 1 | - |
| CHEMBL162388 | — | — | 1 | - |
| CHEMBL1328 | PENTAGASTRIN | 4.0 | 1 | - |
| CHEMBL162600 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64605 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL415630 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL1121 | SINCALIDE | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL120632 | TETRAGASTRIN | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL1121 | SINCALIDE | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL163010 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL2371390 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL352674 | — | Ki | = | 24000.0 | nM | 4.62 |
| CHEMBL352070 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL32301 | — | Ki | = | 75000.0 | nM | 4.12 |
| CHEMBL163210 | — | Ki | = | 5200000.0 | nM | - |
| CHEMBL162388 | — | Ki | = | 1000000000.0 | nM | - |
| CHEMBL1328 | PENTAGASTRIN | Ki | = | 600000000.0 | nM | - |
| CHEMBL162600 | — | Ki | = | 5300000.0 | nM | - |