Assay Detail
Binding
CHEMBL664356
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Inhibitory activity against Trypanosoma cruzi dihydrofolate reductase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.92 | 10.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 10.42 |
| CHEMBL35364 | — | — | 1 | 9.97 |
| CHEMBL284943 | — | — | 1 | 9.88 |
| CHEMBL35427 | — | — | 1 | 9.74 |
| CHEMBL285474 | — | — | 1 | 7.85 |
| CHEMBL35552 | — | — | 1 | 7.33 |
| CHEMBL265757 | — | — | 1 | 7.25 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.038 | nM | 10.42 |
| CHEMBL35364 | — | Ki | = | 0.107 | nM | 9.97 |
| CHEMBL284943 | — | Ki | = | 0.131 | nM | 9.88 |
| CHEMBL35427 | — | Ki | = | 0.183 | nM | 9.74 |
| CHEMBL285474 | — | Ki | = | 14.1 | nM | 7.85 |
| CHEMBL35552 | — | Ki | = | 46.2 | nM | 7.33 |
| CHEMBL265757 | — | Ki | = | 55.7 | nM | 7.25 |