Assay Detail
Binding
CHEMBL664357
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant Dihydrofolate reductase from Trypanosoma cruzi.
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Trypanosoma cruzi |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and evaluation of inhibitors of trypanosomal and leishmanial dihydrofolate reductase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 20 | 6.33 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL334919 | — | — | 1 | 7.64 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 7.01 |
| CHEMBL274031 | — | — | 1 | 6.70 |
| CHEMBL137305 | — | — | 1 | 6.68 |
| CHEMBL343271 | — | — | 1 | 6.68 |
| CHEMBL31946 | — | — | 1 | 6.66 |
| CHEMBL326989 | — | — | 1 | 6.64 |
| CHEMBL344592 | — | — | 1 | 6.44 |
| CHEMBL137448 | — | — | 1 | 6.37 |
| CHEMBL343127 | — | — | 1 | 6.29 |
| CHEMBL31547 | — | — | 1 | 6.22 |
| CHEMBL135935 | — | — | 1 | 6.15 |
| CHEMBL137641 | — | — | 1 | 6.00 |
| CHEMBL18967 | — | — | 1 | 6.00 |
| CHEMBL30734 | — | — | 1 | 6.00 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.00 |
| CHEMBL31235 | — | — | 1 | 5.95 |
| CHEMBL285209 | — | — | 1 | 5.88 |
| CHEMBL138230 | — | — | 1 | 5.82 |
| CHEMBL334695 | — | — | 1 | 5.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL334919 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 98.0 | nM | 7.01 |
| CHEMBL274031 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL137305 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL343271 | — | Ki | = | 210.0 | nM | 6.68 |
| CHEMBL31946 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL326989 | — | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL344592 | — | Ki | = | 360.0 | nM | 6.44 |
| CHEMBL137448 | — | Ki | = | 430.0 | nM | 6.37 |
| CHEMBL343127 | — | Ki | = | 510.0 | nM | 6.29 |
| CHEMBL31547 | — | Ki | = | 600.0 | nM | 6.22 |
| CHEMBL135935 | — | Ki | = | 710.0 | nM | 6.15 |
| CHEMBL137641 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL18967 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL30734 | — | Ki | = | 990.0 | nM | 6.00 |
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL31235 | — | Ki | = | 1130.0 | nM | 5.95 |
| CHEMBL285209 | — | Ki | = | 1330.0 | nM | 5.88 |
| CHEMBL138230 | — | Ki | = | 1500.0 | nM | 5.82 |
| CHEMBL334695 | — | Ki | = | 3110.0 | nM | 5.51 |