Assay Detail
Binding
CHEMBL664374
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Inhibition against Dihydrofolate reductase in Pneumocystis carinii
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Effect of N9-methylation and bridge atom variation on the activity of 5-substituted 2,4-diaminopyrrolo[2,3-d]pyrimidines against dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.92 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 9.00 |
| CHEMBL17232 | — | — | 1 | 7.42 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.42 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL17287 | — | — | 1 | 7.36 |
| CHEMBL17479 | — | — | 1 | 4.97 |
| CHEMBL17431 | — | — | 1 | 4.96 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
| CHEMBL278013 | — | — | 1 | 4.55 |
| CHEMBL17873 | — | — | 1 | 4.45 |
| CHEMBL17323 | — | — | 1 | 4.34 |
| CHEMBL17430 | — | — | 1 | 4.23 |
| CHEMBL17453 | — | — | 1 | - |
| CHEMBL276734 | — | — | 1 | - |
| CHEMBL275893 | — | — | 1 | - |
| CHEMBL278261 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL17232 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL17287 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL17479 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL17431 | — | IC50 | = | 11100.0 | nM | 4.96 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL278013 | — | IC50 | = | 28300.0 | nM | 4.55 |
| CHEMBL17873 | — | IC50 | = | 35300.0 | nM | 4.45 |
| CHEMBL17323 | — | IC50 | = | 45700.0 | nM | 4.34 |
| CHEMBL17430 | — | IC50 | = | 58500.0 | nM | 4.23 |
| CHEMBL17453 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL276734 | — | IC50 | = | 307000.0 | nM | - |
| CHEMBL275893 | — | IC50 | = | 929000.0 | nM | - |
| CHEMBL278261 | — | IC50 | = | 209000.0 | nM | - |