Assay Detail
Binding
CHEMBL664409
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biochemical evaluation of analogues of aminoglutethimide based on phenylpyrrolidine-2,5-dione.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 5.96 | 6.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL488 | AMINOGLUTETHIMIDE | 4.0 | 1 | 6.17 |
| CHEMBL149238 | — | — | 1 | 6.10 |
| CHEMBL151212 | — | — | 1 | 6.00 |
| CHEMBL357775 | — | — | 1 | 5.76 |
| CHEMBL151691 | — | — | 1 | 5.76 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL488 | AMINOGLUTETHIMIDE | Ki | = | 680.0 | nM | 6.17 |
| CHEMBL149238 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL151212 | — | Ki | = | 1000.0 | nM | 6.00 |
| CHEMBL357775 | — | Ki | = | 1750.0 | nM | 5.76 |
| CHEMBL151691 | — | Ki | = | 1750.0 | nM | 5.76 |