Assay Detail
Binding
CHEMBL664429
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Binding affinity was reported with purified recombinant Pneumocystis carinii Dihydrofolate reductase
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New drug developments for opportunistic infections in immunosuppressed patients: Pneumocystis carinii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 8.32 | 9.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 9.85 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 9.15 |
| CHEMBL280378 | EPIROPRIM | 2.0 | 1 | 8.47 |
| CHEMBL36 | PYRIMETHAMINE | 4.0 | 1 | 8.01 |
| CHEMBL747 | CYCLOGUANIL | 2.0 | 1 | 7.63 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 6.82 |
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | Ki | = | 0.143 | nM | 9.85 |
| CHEMBL119 | TRIMETREXATE | Ki | = | 0.71 | nM | 9.15 |
| CHEMBL280378 | EPIROPRIM | Ki | = | 3.4 | nM | 8.47 |
| CHEMBL36 | PYRIMETHAMINE | Ki | = | 9.7 | nM | 8.01 |
| CHEMBL747 | CYCLOGUANIL | Ki | = | 23.3 | nM | 7.63 |
| CHEMBL22 | TRIMETHOPRIM | Ki | = | 152.0 | nM | 6.82 |
| CHEMBL34259 | METHOTREXATE | Ki | = | 0.008 | nM | - |