Assay Detail
Binding
CHEMBL664432
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Inhibitory activity against Pneumocystis carinii dihydrofolate reductase (in 90 uM dihydrofolic acid)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
2,4-diamino-5-deaza-6-substituted pyrido[2,3-d]pyrimidine antifolates as potent and selective nonclassical inhibitors of dihydrofolate reductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.83 | 8.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | 4.0 | 1 | 8.89 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL32190 | — | — | 1 | 7.21 |
| CHEMBL33038 | — | — | 1 | 7.17 |
| CHEMBL36245 | — | — | 1 | 7.12 |
| CHEMBL35222 | — | — | 1 | 7.10 |
| CHEMBL32113 | — | — | 1 | 7.08 |
| CHEMBL34337 | — | — | 1 | 5.75 |
| CHEMBL33136 | — | — | 1 | 5.71 |
| CHEMBL280378 | EPIROPRIM | 2.0 | 1 | 5.58 |
| CHEMBL286700 | — | — | 1 | 5.57 |
| CHEMBL32708 | — | — | 1 | 5.42 |
| CHEMBL32635 | — | — | 1 | 5.41 |
| CHEMBL32769 | — | — | 1 | 5.32 |
| CHEMBL284849 | — | — | 1 | 5.26 |
| CHEMBL32266 | — | — | 1 | 5.24 |
| CHEMBL32220 | — | — | 1 | 5.09 |
| CHEMBL32583 | — | — | 1 | 5.04 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
| CHEMBL33208 | — | — | 1 | 4.85 |
| CHEMBL35569 | — | — | 1 | 4.82 |
| CHEMBL33357 | — | — | 1 | 4.81 |
| CHEMBL32754 | — | — | 1 | 4.68 |
| CHEMBL33187 | — | — | 1 | 4.61 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL34259 | METHOTREXATE | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL32190 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL33038 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL36245 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL35222 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL32113 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL34337 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL33136 | — | IC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL280378 | EPIROPRIM | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL286700 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL32708 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL32635 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL32769 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL284849 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL32266 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL32220 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL32583 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL33208 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL35569 | — | IC50 | = | 15300.0 | nM | 4.82 |
| CHEMBL33357 | — | IC50 | = | 15400.0 | nM | 4.81 |
| CHEMBL32754 | — | IC50 | = | 20700.0 | nM | 4.68 |
| CHEMBL33187 | — | IC50 | = | 24300.0 | nM | 4.61 |