Assay Detail
Binding
CHEMBL664460
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Inhibitory activity against dihydropteroic acid synthase (SYN) from candida albicans
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Candida albicans |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.41 | 5.91 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48396 | ACEDIASULFONE | 2.0 | 1 | 5.91 |
| CHEMBL352594 | — | — | 1 | 5.88 |
| CHEMBL1043 | DAPSONE | 4.0 | 1 | 5.75 |
| CHEMBL143174 | — | — | 1 | 5.62 |
| CHEMBL143106 | — | — | 1 | 5.56 |
| CHEMBL353260 | — | — | 1 | 5.55 |
| CHEMBL358252 | — | — | 1 | 5.50 |
| CHEMBL139596 | — | — | 1 | 5.42 |
| CHEMBL143754 | — | — | 1 | 5.04 |
| CHEMBL142844 | — | — | 1 | 5.00 |
| CHEMBL357499 | — | — | 1 | 4.88 |
| CHEMBL140629 | — | — | 1 | 4.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48396 | ACEDIASULFONE | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL352594 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL1043 | DAPSONE | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL143174 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL143106 | — | IC50 | = | 2780.0 | nM | 5.56 |
| CHEMBL353260 | — | IC50 | = | 2810.0 | nM | 5.55 |
| CHEMBL358252 | — | IC50 | = | 3160.0 | nM | 5.50 |
| CHEMBL139596 | — | IC50 | = | 3830.0 | nM | 5.42 |
| CHEMBL143754 | — | IC50 | = | 9050.0 | nM | 5.04 |
| CHEMBL142844 | — | IC50 | = | 10110.0 | nM | 5.00 |
| CHEMBL357499 | — | IC50 | = | 13260.0 | nM | 4.88 |
| CHEMBL140629 | — | IC50 | = | 14330.0 | nM | 4.84 |