Assay Detail
Binding
CHEMBL664461
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Inhibitory activity against dihydropteroic acid synthase (SYN) from Escherichia coli
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Escherichia coli |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Folate-synthesizing enzyme system as target for development of inhibitors and inhibitor combinations against Candida albicans-synthesis and biological activity of new 2,4-diaminopyrimidines and 4'-substituted 4-aminodiphenyl sulfones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.30 | 4.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL143174 | — | — | 1 | 4.46 |
| CHEMBL1043 | DAPSONE | 4.0 | 1 | 4.46 |
| CHEMBL48396 | ACEDIASULFONE | 2.0 | 1 | 4.43 |
| CHEMBL358252 | — | — | 1 | 4.38 |
| CHEMBL353260 | — | — | 1 | 4.33 |
| CHEMBL143106 | — | — | 1 | 4.13 |
| CHEMBL1246 | MONO-N-ACETYL DAPSONE | — | 1 | 4.12 |
| CHEMBL142844 | — | — | 1 | 4.05 |
| CHEMBL357499 | — | — | 1 | - |
| CHEMBL172231 | — | — | 1 | - |
| CHEMBL143754 | — | — | 1 | - |
| CHEMBL352594 | — | — | 1 | - |
| CHEMBL140585 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL143174 | — | IC50 | = | 34920.0 | nM | 4.46 |
| CHEMBL1043 | DAPSONE | IC50 | = | 34360.0 | nM | 4.46 |
| CHEMBL48396 | ACEDIASULFONE | IC50 | = | 37050.0 | nM | 4.43 |
| CHEMBL358252 | — | IC50 | = | 41710.0 | nM | 4.38 |
| CHEMBL353260 | — | IC50 | = | 46210.0 | nM | 4.33 |
| CHEMBL143106 | — | IC50 | = | 74240.0 | nM | 4.13 |
| CHEMBL1246 | MONO-N-ACETYL DAPSONE | IC50 | = | 75650.0 | nM | 4.12 |
| CHEMBL142844 | — | IC50 | = | 89850.0 | nM | 4.05 |
| CHEMBL357499 | — | IC50 | = | 116000.0 | nM | - |
| CHEMBL172231 | — | IC50 | = | 155390.0 | nM | - |
| CHEMBL143754 | — | IC50 | = | 128200.0 | nM | - |
| CHEMBL352594 | — | IC50 | = | 101240.0 | nM | - |
| CHEMBL140585 | — | IC50 | = | 149000.0 | nM | - |