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Assay Detail

CHEMBL664530

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Binding
Inhibitory concentration against Dipeptidylpeptidase IV
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

An aminomethylpyrimidine DPP-IV inhibitor with improved properties.
Peters JU, Hunziker D, Fischer H, Kansy M, Weber S, Kritter S, Müller A, Wallier A, Ricklin F, Boehringer M, Poli SM, Csato M, Loeffler BM.
Bioorg Med Chem Lett (2004) 14 : 3575 -3578
PubMed 15177477 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 7.73 9.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL332123 1 9.70
CHEMBL116373 1 9.30
CHEMBL324777 1 8.05
CHEMBL36020 1 8.00
CHEMBL120118 1 7.96
CHEMBL120625 1 7.62
CHEMBL120039 1 7.26
CHEMBL119319 1 7.10
CHEMBL262045 1 6.85
CHEMBL119971 1 6.60
CHEMBL122474 1 6.57

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL332123 IC50 = 0.2 nM 9.70
CHEMBL116373 IC50 = 0.5 nM 9.30
CHEMBL324777 IC50 = 9.0 nM 8.05
CHEMBL36020 IC50 = 10.0 nM 8.00
CHEMBL120118 IC50 = 11.0 nM 7.96
CHEMBL120625 IC50 = 24.0 nM 7.62
CHEMBL120039 IC50 = 55.0 nM 7.26
CHEMBL119319 IC50 = 79.0 nM 7.10
CHEMBL262045 IC50 = 140.0 nM 6.85
CHEMBL119971 IC50 = 250.0 nM 6.60
CHEMBL122474 IC50 = 270.0 nM 6.57