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Assay Detail

CHEMBL664531

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Binding
Inhibition of Dipeptidylpeptidase IV
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Aminomethylpyridines as DPP-IV inhibitors.
Peters JU, Weber S, Kritter S, Weiss P, Wallier A, Zimmerli D, Boehringer M, Steger M, Loeffler BM.
Bioorg Med Chem Lett (2004) 14 : 3579 -3580
PubMed 15177478 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 6.52 8.15

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL122206 1 8.15
CHEMBL127550 1 7.41
CHEMBL124775 1 7.35
CHEMBL411528 1 7.09
CHEMBL334205 1 6.89
CHEMBL339595 1 6.72
CHEMBL122287 1 6.62
CHEMBL333672 1 6.55
CHEMBL123728 1 6.04
CHEMBL331950 1 6.04
CHEMBL37980 1 5.00
CHEMBL421267 1 4.33

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL122206 IC50 = 7.0 nM 8.15
CHEMBL127550 IC50 = 39.0 nM 7.41
CHEMBL124775 IC50 = 45.0 nM 7.35
CHEMBL411528 IC50 = 82.0 nM 7.09
CHEMBL334205 IC50 = 130.0 nM 6.89
CHEMBL339595 IC50 = 190.0 nM 6.72
CHEMBL122287 IC50 = 240.0 nM 6.62
CHEMBL333672 IC50 = 280.0 nM 6.55
CHEMBL123728 IC50 = 910.0 nM 6.04
CHEMBL331950 IC50 = 920.0 nM 6.04
CHEMBL37980 IC50 = 10000.0 nM 5.00
CHEMBL421267 IC50 = 47000.0 nM 4.33