Assay Detail
Binding
CHEMBL664534
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Inhibitory activity against Dipeptidylpeptidase IV (DPP IV)
64
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Design, synthesis, and SAR of potent and selective dipeptide-derived inhibitors for dipeptidyl peptidases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 4.85 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL319514 | — | — | 1 | 6.70 |
| CHEMBL461912 | — | — | 1 | 6.50 |
| CHEMBL357606 | — | — | 1 | 5.77 |
| CHEMBL148261 | — | — | 1 | 5.46 |
| CHEMBL503274 | — | — | 1 | 5.40 |
| CHEMBL383705 | — | — | 1 | 5.40 |
| CHEMBL317126 | — | — | 1 | 4.85 |
| CHEMBL403882 | — | — | 1 | 4.82 |
| CHEMBL278393 | — | — | 1 | 4.77 |
| CHEMBL145862 | — | — | 1 | 4.74 |
| CHEMBL93931 | — | — | 1 | 4.68 |
| CHEMBL317944 | — | — | 1 | 4.64 |
| CHEMBL328694 | — | — | 1 | 4.41 |
| CHEMBL443622 | — | — | 1 | 4.39 |
| CHEMBL346877 | — | — | 1 | 4.30 |
| CHEMBL145813 | — | — | 1 | 4.29 |
| CHEMBL444537 | — | — | 1 | 4.28 |
| CHEMBL93507 | — | — | 1 | 4.17 |
| CHEMBL146995 | — | — | 1 | 4.17 |
| CHEMBL148954 | — | — | 1 | 4.09 |
| CHEMBL147691 | — | — | 1 | 4.03 |
| CHEMBL148955 | — | — | 2 | - |
| CHEMBL148002 | — | — | 1 | - |
| CHEMBL344507 | — | — | 1 | - |
| CHEMBL97025 | — | — | 1 | - |
| CHEMBL343650 | — | — | 1 | - |
| CHEMBL328795 | — | — | 1 | - |
| CHEMBL343907 | — | — | 1 | - |
| CHEMBL148569 | — | — | 1 | - |
| CHEMBL148285 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL319514 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL461912 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL357606 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL148261 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL503274 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL383705 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL317126 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL403882 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL278393 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL145862 | — | IC50 | = | 18100.0 | nM | 4.74 |
| CHEMBL93931 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL317944 | — | IC50 | = | 23100.0 | nM | 4.64 |
| CHEMBL328694 | — | IC50 | = | 39000.0 | nM | 4.41 |
| CHEMBL443622 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL346877 | — | IC50 | = | 50400.0 | nM | 4.30 |
| CHEMBL145813 | — | IC50 | = | 51000.0 | nM | 4.29 |
| CHEMBL444537 | — | IC50 | = | 52000.0 | nM | 4.28 |
| CHEMBL93507 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL146995 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL148954 | — | IC50 | = | 81000.0 | nM | 4.09 |
| CHEMBL147691 | — | IC50 | = | 93000.0 | nM | 4.03 |
| CHEMBL145855 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL147314 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL147923 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL148461 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL461506 | — | IC50 | = | 134900.0 | nM | - |
| CHEMBL146450 | — | IC50 | >> | 1000000.0 | nM | - |
| CHEMBL147583 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL147923 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL148955 | — | IC50 | = | 318000.0 | nM | - |
| CHEMBL434886 | — | IC50 | = | 167000.0 | nM | - |
| CHEMBL146509 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL148026 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL499101 | — | IC50 | = | 122000.0 | nM | - |
| CHEMBL359211 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL149498 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL461506 | — | IC50 | = | 247000.0 | nM | - |
| CHEMBL97064 | — | IC50 | = | 190000.0 | nM | - |
| CHEMBL329171 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL148002 | — | IC50 | = | 360000.0 | nM | - |
| CHEMBL348246 | — | IC50 | = | 500000.0 | nM | - |
| CHEMBL148285 | — | IC50 | = | 250000.0 | nM | - |
| CHEMBL148569 | — | IC50 | - | nM | - | |
| CHEMBL343907 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL328795 | — | IC50 | = | 188000.0 | nM | - |
| CHEMBL343650 | — | IC50 | = | 377000.0 | nM | - |
| CHEMBL97025 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL344507 | — | IC50 | > | 125000.0 | nM | - |
| CHEMBL148955 | — | IC50 | = | 318000.0 | nM | - |
| CHEMBL144027 | — | IC50 | = | 500000.0 | nM | - |