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Assay Detail

CHEMBL664554

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of DNA interaction using DNA Methyl Green Assay.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 3 — Cell-line / Tissue
Curated By Expert

Target

Nucleic Acid (CHEMBL345)
Type NUCLEIC-ACID

Publication

Synthesis, cytotoxicity, and antiplasmodial and antitrypanosomal activity of new neocryptolepine derivatives.
Jonckers TH, van Miert S, Cimanga K, Bailly C, Colson P, De Pauw-Gillet MC, van den Heuvel H, Claeys M, Lemière F, Esmans EL, Rozenski J, Quirijnen L, Maes L, Dommisse R, Lemière GL, Vlietinck A, Pieters L.
J Med Chem (2002) 45 : 3497 -3508
PubMed 12139461 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 24 4.11 4.18

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL119096 CRYPTOLEPINE 1 4.18
CHEMBL119649 1 4.11
CHEMBL115585 NEOCRYPTOLEPINE 1 4.03
CHEMBL118340 1 -
CHEMBL118066 1 -
CHEMBL115592 1 -
CHEMBL118855 1 -
CHEMBL118165 1 -
CHEMBL432423 1 -
CHEMBL323909 1 -
CHEMBL117831 1 -
CHEMBL117064 1 -
CHEMBL118916 1 -
CHEMBL443023 1 -
CHEMBL115433 1 -
CHEMBL332478 1 -
CHEMBL331251 1 -
CHEMBL117926 1 -
CHEMBL119102 1 -
CHEMBL118343 1 -
CHEMBL440898 1 -
CHEMBL118915 1 -
CHEMBL118838 1 -
CHEMBL119475 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL119096 CRYPTOLEPINE IC50 = 65700.0 nM 4.18
CHEMBL119649 IC50 = 77900.0 nM 4.11
CHEMBL115585 NEOCRYPTOLEPINE IC50 = 92800.0 nM 4.03
CHEMBL118340 IC50 > 400000.0 nM -
CHEMBL118066 IC50 > 600000.0 nM -
CHEMBL115592 IC50 > 400000.0 nM -
CHEMBL118855 IC50 > 500000.0 nM -
CHEMBL118165 IC50 > 500000.0 nM -
CHEMBL432423 IC50 > 600000.0 nM -
CHEMBL323909 IC50 > 1000000.0 nM -
CHEMBL117831 IC50 > 200000.0 nM -
CHEMBL117064 IC50 > 1000000.0 nM -
CHEMBL118916 IC50 > 500000.0 nM -
CHEMBL443023 IC50 > 1000000.0 nM -
CHEMBL115433 IC50 > 600000.0 nM -
CHEMBL332478 IC50 > 600000.0 nM -
CHEMBL331251 IC50 > 1000000.0 nM -
CHEMBL117926 IC50 > 500000.0 nM -
CHEMBL119102 IC50 > 600000.0 nM -
CHEMBL118343 IC50 > 1000000.0 nM -
CHEMBL440898 IC50 > 400000.0 nM -
CHEMBL118915 IC50 = 150300.0 nM -
CHEMBL118838 IC50 > 700000.0 nM -
CHEMBL119475 IC50 > 1000000.0 nM -