Assay Detail
Binding
CHEMBL664584
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Inhibition of human placental Cytochrome P450 19A1
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Inhibition of human placental aromatase by novel homologated 19-oxiranyl and 19-thiiranyl steroids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 7.37 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281433 | — | — | 1 | 9.00 |
| CHEMBL26093 | — | — | 1 | 8.15 |
| CHEMBL2113272 | — | — | 1 | 7.66 |
| CHEMBL282580 | — | — | 1 | 7.12 |
| CHEMBL28806 | — | — | 1 | 7.12 |
| CHEMBL2113269 | — | — | 1 | 7.07 |
| CHEMBL2113276 | — | — | 1 | 6.69 |
| CHEMBL2113268 | — | — | 1 | 6.12 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281433 | — | Ki | = | 1.0 | nM | 9.00 |
| CHEMBL26093 | — | Ki | = | 7.0 | nM | 8.15 |
| CHEMBL2113272 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL282580 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL28806 | — | Ki | = | 75.0 | nM | 7.12 |
| CHEMBL2113269 | — | Ki | = | 86.0 | nM | 7.07 |
| CHEMBL2113276 | — | Ki | = | 206.0 | nM | 6.69 |
| CHEMBL2113268 | — | Ki | = | 753.0 | nM | 6.12 |