Assay Detail
Binding
CHEMBL664743
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Binding affinity was measured on cloned Human D2A Receptor which is labeled by [3H]raclopride
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Derivatives of (R)-1,11-methyleneaporphine: synthesis, structure, and interactions with G-protein coupled receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 6.76 | 7.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL282863 | — | — | 1 | 7.71 |
| CHEMBL27132 | — | — | 1 | 7.41 |
| CHEMBL53 | APOMORPHINE | 4.0 | 1 | 7.38 |
| CHEMBL284586 | — | — | 1 | 7.08 |
| CHEMBL27940 | — | — | 1 | 6.70 |
| CHEMBL281357 | — | — | 1 | 6.28 |
| CHEMBL26998 | — | — | 1 | 6.09 |
| CHEMBL22778 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL282863 | — | Ki | = | 19.4 | nM | 7.71 |
| CHEMBL27132 | — | Ki | = | 39.2 | nM | 7.41 |
| CHEMBL53 | APOMORPHINE | Ki | = | 41.6 | nM | 7.38 |
| CHEMBL284586 | — | Ki | = | 83.2 | nM | 7.08 |
| CHEMBL27940 | — | Ki | = | 201.0 | nM | 6.70 |
| CHEMBL281357 | — | Ki | = | 527.0 | nM | 6.28 |
| CHEMBL26998 | — | Ki | = | 819.0 | nM | 6.09 |
| CHEMBL22778 | — | Ki | = | 3760.0 | nM | 5.42 |