Assay Detail
Binding
CHEMBL664766
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Apparent binding affinity against DNA (5'-ACAATTAA-3') was determined using DNase I footprinting titration method
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Expert |
Publication
DNA binding ligands targeting drug-resistant bacteria: structure, activity, and pharmacology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 14 | 8.23 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL340601 | — | — | 1 | 10.00 |
| CHEMBL339539 | — | — | 1 | 9.70 |
| CHEMBL338292 | — | — | 1 | 9.00 |
| CHEMBL340626 | — | — | 1 | 8.70 |
| CHEMBL129791 | — | — | 1 | 8.30 |
| CHEMBL340941 | — | — | 1 | 8.30 |
| CHEMBL341509 | — | — | 1 | 8.30 |
| CHEMBL434628 | — | — | 1 | 7.70 |
| CHEMBL341285 | — | — | 1 | 7.30 |
| CHEMBL128651 | — | — | 1 | 7.30 |
| CHEMBL338676 | — | — | 1 | 7.15 |
| CHEMBL129348 | — | — | 1 | 7.00 |
| CHEMBL339310 | — | — | 1 | - |
| CHEMBL129128 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL340601 | — | Kd | = | 0.1 | nM | 10.00 |
| CHEMBL339539 | — | Kd | = | 0.2 | nM | 9.70 |
| CHEMBL338292 | — | Kd | = | 1.0 | nM | 9.00 |
| CHEMBL340626 | — | Kd | = | 2.0 | nM | 8.70 |
| CHEMBL129791 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL340941 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL341509 | — | Kd | = | 5.0 | nM | 8.30 |
| CHEMBL434628 | — | Kd | = | 20.0 | nM | 7.70 |
| CHEMBL341285 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL128651 | — | Kd | = | 50.0 | nM | 7.30 |
| CHEMBL338676 | — | Kd | = | 71.0 | nM | 7.15 |
| CHEMBL129348 | — | Kd | = | 100.0 | nM | 7.00 |
| CHEMBL339310 | — | Kd | < | 0.1 | nM | - |
| CHEMBL129128 | — | Kd | < | 1.0 | nM | - |