Assay Detail
Binding
CHEMBL664889
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Binding affinity for human placental microsome cytochrome P450 19A1 with 1 uM [1-beta-3H]-androstenedione
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and biochemical studies of 16- or 19-substituted androst-4-enes as aromatase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 6.57 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1629805 | — | — | 1 | 7.89 |
| CHEMBL1629804 | — | — | 1 | 7.43 |
| CHEMBL440691 | — | — | 1 | 6.77 |
| CHEMBL83422 | — | — | 1 | 6.64 |
| CHEMBL309656 | — | — | 1 | 6.54 |
| CHEMBL83835 | — | — | 1 | 6.35 |
| CHEMBL81134 | — | — | 1 | 6.34 |
| CHEMBL439950 | — | — | 1 | 6.08 |
| CHEMBL82981 | — | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1629805 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL1629804 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL440691 | — | Ki | = | 170.0 | nM | 6.77 |
| CHEMBL83422 | — | Ki | = | 228.0 | nM | 6.64 |
| CHEMBL309656 | — | Ki | = | 289.0 | nM | 6.54 |
| CHEMBL83835 | — | Ki | = | 443.0 | nM | 6.35 |
| CHEMBL81134 | — | Ki | = | 455.0 | nM | 6.34 |
| CHEMBL439950 | — | Ki | = | 830.0 | nM | 6.08 |
| CHEMBL82981 | — | Ki | = | 7750.0 | nM | 5.11 |