Assay Detail
Binding
CHEMBL664893
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Catalytic rate constant (Ki) for time-dependent inactivation of Cytochrome P450 19A1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Time-dependent inactivation of aromatase by 6-alkylandrosta-1,4-diene-3,17-diones. Effects of length and configuration of 6-alkyl group.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.26 | 6.71 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL8498 | — | — | 1 | 6.71 |
| CHEMBL8333 | — | — | 1 | 6.47 |
| CHEMBL8646 | — | — | 1 | 6.24 |
| CHEMBL266532 | — | — | 1 | 6.19 |
| CHEMBL8315 | — | — | 1 | 6.12 |
| CHEMBL274878 | — | — | 1 | 6.10 |
| CHEMBL1078534 | ANDROSTENEDONE | — | 1 | 6.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL8498 | — | Ki | = | 196.0 | nM | 6.71 |
| CHEMBL8333 | — | Ki | = | 339.0 | nM | 6.47 |
| CHEMBL8646 | — | Ki | = | 571.0 | nM | 6.24 |
| CHEMBL266532 | — | Ki | = | 650.0 | nM | 6.19 |
| CHEMBL8315 | — | Ki | = | 757.0 | nM | 6.12 |
| CHEMBL274878 | — | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL1078534 | ANDROSTENEDONE | Ki | = | 952.0 | nM | 6.02 |