Assay Detail

CHEMBL664897

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Binding

Competitive inhibition of human placental Cytochrome P450 19A1

ChEMBL ↗

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Target

Aromatase (CHEMBL1978) ↗

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Primary target Aromatase

CHEMBL1978

Anchored from Assay target.

Protein identity Aromatase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	9 — Direct single protein target
Curated By	Expert

Target

Aromatase (CHEMBL1978) ↗

Type	SINGLE PROTEIN
Organism	Homo sapiens

Publication

Fadrozole hydrochloride: a potent, selective, nonsteroidal inhibitor of aromatase for the treatment of estrogen-dependent disease.

Browne LJ, Gude C, Rodriguez H, Steele RE, Bhatnager A.
J Med Chem (1991) 34 : 725 -736
PubMed 1825337 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
Ki	1	6.33	6.33

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL488	AMINOGLUTETHIMIDE	4.0	1	6.33

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL488	AMINOGLUTETHIMIDE	Ki	=	470.0	nM	6.33