Assay Detail
Binding
CHEMBL664909
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration inhibiting Toxoplasma gondii dihydrofolate reductase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.82 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 9.07 |
| CHEMBL52688 | — | — | 1 | 8.33 |
| CHEMBL88555 | — | — | 1 | 8.28 |
| CHEMBL328897 | — | — | 1 | 8.19 |
| CHEMBL23532 | — | — | 1 | 8.13 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL89528 | — | — | 1 | 7.82 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.77 |
| CHEMBL54399 | — | — | 1 | 7.70 |
| CHEMBL82975 | — | — | 1 | 7.57 |
| CHEMBL88430 | — | — | 1 | 7.52 |
| CHEMBL55179 | — | — | 1 | 7.09 |
| CHEMBL300603 | — | — | 1 | 7.01 |
| CHEMBL52947 | — | — | 1 | 7.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL52688 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL88555 | — | IC50 | = | 5.2 | nM | 8.28 |
| CHEMBL328897 | — | IC50 | = | 6.4 | nM | 8.19 |
| CHEMBL23532 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL89528 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL54399 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL82975 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL88430 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL55179 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL300603 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL52947 | — | IC50 | = | 100.0 | nM | 7.00 |