Assay Detail
Binding
CHEMBL664916
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Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Toxoplasma gondii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Bifunctional dihydrofolate reductase-thymidylate synthase (CHEMBL2425) ↗| Type | SINGLE PROTEIN |
| Organism | Toxoplasma gondii |
Publication
6-substituted 2,4-diamino-5-methylpyrido[2,3-d]pyrimidines as inhibitors of dihydrofolate reductases from Pneumocystis carinii and Toxoplasma gondii and as antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 7.75 | 9.07 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 9.07 |
| CHEMBL52433 | — | — | 1 | 8.57 |
| CHEMBL23569 | — | — | 1 | 8.32 |
| CHEMBL53693 | — | — | 1 | 8.17 |
| CHEMBL23532 | — | — | 1 | 8.13 |
| CHEMBL49454 | — | — | 1 | 8.11 |
| CHEMBL283518 | — | — | 1 | 8.06 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 8.00 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.96 |
| CHEMBL23867 | — | — | 1 | 7.84 |
| CHEMBL23021 | — | — | 1 | 7.80 |
| CHEMBL279679 | — | — | 1 | 7.77 |
| CHEMBL53903 | — | — | 1 | 7.64 |
| CHEMBL279680 | — | — | 1 | 7.54 |
| CHEMBL281803 | — | — | 1 | 7.52 |
| CHEMBL23705 | — | — | 1 | 7.42 |
| CHEMBL279983 | — | — | 1 | 7.25 |
| CHEMBL22623 | — | — | 1 | 7.24 |
| CHEMBL23844 | — | — | 1 | 7.00 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 5.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 0.85 | nM | 9.07 |
| CHEMBL52433 | — | IC50 | = | 2.7 | nM | 8.57 |
| CHEMBL23569 | — | IC50 | = | 4.8 | nM | 8.32 |
| CHEMBL53693 | — | IC50 | = | 6.7 | nM | 8.17 |
| CHEMBL23532 | — | IC50 | = | 7.4 | nM | 8.13 |
| CHEMBL49454 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL283518 | — | IC50 | = | 8.8 | nM | 8.06 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL23867 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL23021 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL279679 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL53903 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL279680 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL281803 | — | IC50 | = | 30.1 | nM | 7.52 |
| CHEMBL23705 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL279983 | — | IC50 | = | 56.5 | nM | 7.25 |
| CHEMBL22623 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL23844 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 2700.0 | nM | 5.57 |