Assay Detail
Binding
CHEMBL664933
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human Dipeptidyl peptidase IV
14
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
4-cyanothiazolidides as very potent, stable inhibitors of dipeptidyl peptidase IV
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 14 | 7.68 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL93208 | — | — | 1 | 9.39 |
| CHEMBL93060 | — | — | 1 | 9.30 |
| CHEMBL316560 | — | — | 1 | 9.10 |
| CHEMBL94278 | — | — | 1 | 8.96 |
| CHEMBL327187 | — | — | 1 | 8.77 |
| CHEMBL329641 | — | — | 1 | 8.66 |
| CHEMBL92175 | — | — | 1 | 8.30 |
| CHEMBL92760 | — | — | 1 | 7.68 |
| CHEMBL2115247 | — | — | 2 | 7.47 |
| CHEMBL93526 | — | — | 1 | 6.58 |
| CHEMBL328123 | — | — | 1 | 6.35 |
| CHEMBL92706 | — | — | 1 | 5.38 |
| CHEMBL315163 | — | — | 1 | 5.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL93208 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL93060 | — | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL316560 | — | Ki | = | 0.8 | nM | 9.10 |
| CHEMBL94278 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL327187 | — | Ki | = | 1.7 | nM | 8.77 |
| CHEMBL329641 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL92175 | — | Ki | = | 5.0 | nM | 8.30 |
| CHEMBL92760 | — | Ki | = | 21.0 | nM | 7.68 |
| CHEMBL2115247 | — | Ki | = | 34.0 | nM | 7.47 |
| CHEMBL93526 | — | Ki | = | 260.0 | nM | 6.58 |
| CHEMBL2115247 | — | Ki | = | 440.0 | nM | 6.36 |
| CHEMBL328123 | — | Ki | = | 450.0 | nM | 6.35 |
| CHEMBL92706 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL315163 | — | Ki | = | 6000.0 | nM | 5.22 |