Assay Detail
Binding
CHEMBL665004
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Inhibition of Cyclin Dependent Kinase 4 cyclin D1
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Indenopyrazoles as novel cyclin dependent kinase (CDK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.42 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL281500 | — | — | 1 | 6.70 |
| CHEMBL28377 | — | — | 1 | 6.35 |
| CHEMBL27275 | — | — | 1 | 6.32 |
| CHEMBL280867 | — | — | 1 | 4.46 |
| CHEMBL281470 | — | — | 1 | 4.35 |
| CHEMBL27891 | — | — | 1 | 4.35 |
| CHEMBL27645 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL281500 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL28377 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL27275 | — | IC50 | = | 480.0 | nM | 6.32 |
| CHEMBL280867 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL281470 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL27891 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL27645 | — | IC50 | > | 250000.0 | nM | - |