Assay Detail
Binding
CHEMBL665040
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Inhibition of Pneumocystis carinii dihydrofolate reductase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis of 5-methyl-5-deaza nonclassical antifolates as inhibitors of dihydrofolate reductases and as potential antipneumocystis, antitoxoplasma, and antitumor agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.93 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 7.88 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.42 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL420224 | — | — | 1 | 7.20 |
| CHEMBL23532 | — | — | 1 | 7.07 |
| CHEMBL82975 | — | — | 1 | 7.00 |
| CHEMBL82924 | — | — | 1 | 6.98 |
| CHEMBL81820 | — | — | 1 | 6.50 |
| CHEMBL116614 | — | — | 1 | 6.29 |
| CHEMBL334271 | — | — | 1 | 6.28 |
| CHEMBL115788 | — | — | 1 | 6.26 |
| CHEMBL421053 | — | — | 1 | - |
| CHEMBL114668 | — | — | 1 | - |
| CHEMBL117172 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL420224 | — | IC50 | = | 63.0 | nM | 7.20 |
| CHEMBL23532 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL82975 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL82924 | — | IC50 | = | 104.5 | nM | 6.98 |
| CHEMBL81820 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL116614 | — | IC50 | = | 510.0 | nM | 6.29 |
| CHEMBL334271 | — | IC50 | = | 520.0 | nM | 6.28 |
| CHEMBL115788 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL421053 | — | IC50 | > | 3700.0 | nM | - |
| CHEMBL114668 | — | IC50 | > | 2600.0 | nM | - |
| CHEMBL117172 | — | IC50 | > | 1200.0 | nM | - |