Assay Detail
Binding
CHEMBL665050
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Concentration inhibiting Pneumocystis carinii dihydrofolate reductase
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
2,4-Diaminopyrido[3,2-d]pyrimidine inhibitors of dihydrofolate reductase from Pneumocystis carinii and Toxoplasma gondii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 7.03 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL328897 | — | — | 1 | 7.92 |
| CHEMBL50514 | — | — | 1 | 7.89 |
| CHEMBL300603 | — | — | 1 | 7.66 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.51 |
| CHEMBL88555 | — | — | 1 | 7.48 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL88430 | — | — | 1 | 7.29 |
| CHEMBL89528 | — | — | 1 | 7.21 |
| CHEMBL23532 | — | — | 1 | 7.07 |
| CHEMBL82975 | — | — | 1 | 7.00 |
| CHEMBL52688 | — | — | 1 | 6.89 |
| CHEMBL52947 | — | — | 1 | 5.85 |
| CHEMBL54399 | — | — | 1 | 5.68 |
| CHEMBL55179 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL328897 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL50514 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL300603 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL88555 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL88430 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL89528 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL23532 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL82975 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL52688 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL52947 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL54399 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL55179 | — | IC50 | = | 2600.0 | nM | 5.58 |