Assay Detail
Binding
CHEMBL665129
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Inhibitory activity against cephalosporinase from Proteus vulgaris TH-147 using cephalexin (40 uM) as a substrate
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Proteus vulgaris |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and beta-lactamase inhibitory properties of 2 beta-[(1,2,3-triazol-1-yl)methyl]-2 alpha-methylpenam-3 alpha-carboxylic acid 1,1-dioxide and related triazolyl derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.71 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL285387 | — | — | 1 | 7.22 |
| CHEMBL777 | CLAVULANIC ACID | 4.0 | 1 | 6.80 |
| CHEMBL403 | SULBACTAM | 4.0 | 1 | 6.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL285387 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL777 | CLAVULANIC ACID | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL403 | SULBACTAM | IC50 | = | 800.0 | nM | 6.10 |