Assay Detail
Functional
CHEMBL665146
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COLO 205 human colon tumor cell proliferation
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationships of 3-cyano-4-(phenoxyanilino)quinolines as MEK (MAPKK) inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.16 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL414139 | — | — | 1 | 6.44 |
| CHEMBL95002 | — | — | 1 | 6.20 |
| CHEMBL31733 | — | — | 1 | 5.84 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL414139 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL95002 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL31733 | — | IC50 | = | 1430.0 | nM | 5.84 |