Assay Detail
Binding
CHEMBL665218
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Inhibition of binding to chick skin Cytoplasmic retinoic acid binding protein
7
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Gallus gallus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
Cellular retinoic acid-binding protein 1 (CHEMBL4945) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Conformationally defined 6-s-trans-retinoic acid analogs. 2. Selective agonists for nuclear receptor binding and transcriptional activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 6.11 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | 4.0 | 1 | 6.22 |
| CHEMBL46398 | — | — | 1 | 6.16 |
| CHEMBL547 | ISOTRETINOIN | 4.0 | 1 | 6.05 |
| CHEMBL2111557 | — | — | 2 | 6.00 |
| CHEMBL75548 | — | — | 1 | - |
| CHEMBL72988 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL38 | TRETINOIN | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL46398 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL547 | ISOTRETINOIN | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL2111557 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL75548 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL72988 | — | IC50 | > | 500000.0 | nM | - |
| CHEMBL2111557 | — | IC50 | > | 500000.0 | nM | - |