Assay Detail
Binding
CHEMBL665254
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Inhibitory concentration against Dihydrofolate reductase from Pneumocystis carinii (pc)
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and dihydrofolate reductase inhibitory activities of 2,4-diamino-5-deaza and 2,4-diamino-5,10-dideaza lipophilic antifolates.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 5.96 | 7.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 7.89 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.42 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL356490 | — | — | 1 | 6.72 |
| CHEMBL142741 | — | — | 1 | 6.62 |
| CHEMBL145528 | — | — | 1 | 6.54 |
| CHEMBL145068 | — | — | 1 | 5.85 |
| CHEMBL23288 | — | — | 1 | 5.82 |
| CHEMBL141708 | — | — | 1 | 5.58 |
| CHEMBL142624 | — | — | 1 | 5.30 |
| CHEMBL145005 | — | — | 1 | 5.28 |
| CHEMBL145691 | — | — | 1 | 5.11 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
| CHEMBL342555 | — | — | 1 | 4.73 |
| CHEMBL423558 | — | — | 1 | 4.21 |
| CHEMBL145169 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL356490 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL142741 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL145528 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL145068 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL23288 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL141708 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL142624 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL145005 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL145691 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL342555 | — | IC50 | = | 18500.0 | nM | 4.73 |
| CHEMBL423558 | — | IC50 | = | 61700.0 | nM | 4.21 |
| CHEMBL145169 | — | IC50 | > | 5000.0 | nM | - |