Assay Detail
Binding
CHEMBL665255
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Inhibitory concentration against Pneumocystis carinii Dihydrofolate reductase
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Publication
Synthesis and biological activities of conformationally restricted, tricyclic nonclassical antifolates as inhibitors of dihydrofolate reductases.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 6.39 | 7.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50514 | — | — | 1 | 7.88 |
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.51 |
| CHEMBL119 | TRIMETREXATE | 4.0 | 1 | 7.38 |
| CHEMBL299927 | — | — | 1 | 5.66 |
| CHEMBL57682 | — | — | 1 | 5.62 |
| CHEMBL293512 | — | — | 1 | 5.37 |
| CHEMBL58597 | — | — | 1 | 5.34 |
| CHEMBL60968 | — | — | 1 | - |
| CHEMBL431740 | — | — | 1 | - |
| CHEMBL57637 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50514 | — | IC50 | = | 13.2 | nM | 7.88 |
| CHEMBL7492 | PIRITREXIM | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL119 | TRIMETREXATE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL299927 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL57682 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL293512 | — | IC50 | = | 4280.0 | nM | 5.37 |
| CHEMBL58597 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL60968 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL431740 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL57637 | — | IC50 | > | 2270.0 | nM | - |