Assay Detail
Binding
CHEMBL665259
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The ability to inhibit Pneumocystis carinii Dihydrofolate reductase was tested
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Synthesis and antiparasitic and antitumor activity of 2, 4-diamino-6-(arylmethyl)-5,6,7,8-tetrahydroquinazoline analogues of piritrexim.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 6.20 | 7.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | 2.0 | 1 | 7.51 |
| CHEMBL7375 | — | — | 1 | 7.24 |
| CHEMBL7063 | — | — | 1 | 7.04 |
| CHEMBL266024 | — | — | 1 | 7.00 |
| CHEMBL267616 | — | — | 1 | 7.00 |
| CHEMBL7571 | — | — | 1 | 6.75 |
| CHEMBL267207 | — | — | 1 | 6.68 |
| CHEMBL7542 | — | — | 1 | 6.60 |
| CHEMBL268355 | — | — | 1 | 6.57 |
| CHEMBL6970 | — | — | 1 | 6.54 |
| CHEMBL7779 | — | — | 1 | 6.47 |
| CHEMBL267437 | — | — | 1 | 6.40 |
| CHEMBL7452 | — | — | 1 | 6.36 |
| CHEMBL268870 | — | — | 1 | 6.35 |
| CHEMBL7062 | — | — | 1 | 6.24 |
| CHEMBL7170 | — | — | 1 | 6.06 |
| CHEMBL7586 | — | — | 1 | 5.77 |
| CHEMBL7263 | — | — | 1 | 5.77 |
| CHEMBL7535 | — | — | 1 | 5.66 |
| CHEMBL7139 | — | — | 1 | 5.48 |
| CHEMBL7488 | — | — | 1 | 5.34 |
| CHEMBL6899 | — | — | 1 | 5.16 |
| CHEMBL6696 | — | — | 1 | 5.16 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
| CHEMBL6971 | — | — | 1 | 4.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL7492 | PIRITREXIM | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL7375 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL7063 | — | IC50 | = | 91.0 | nM | 7.04 |
| CHEMBL266024 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267616 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL7571 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL267207 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL7542 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL268355 | — | IC50 | = | 270.0 | nM | 6.57 |
| CHEMBL6970 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL7779 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL267437 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL7452 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL268870 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL7062 | — | IC50 | = | 580.0 | nM | 6.24 |
| CHEMBL7170 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL7586 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL7263 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL7535 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL7139 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL7488 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL6899 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL6696 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL6971 | — | IC50 | = | 15000.0 | nM | 4.82 |