Assay Detail
Binding
CHEMBL665261
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Inhibitory activity against purified DHFR (Dihydrofolate reductase) from Pneumocystis carinii.
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Pneumocystis carinii |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Nonclassical 2,4-diamino-6-(aminomethyl)-5,6,7,8-tetrahydroquinazoline antifolates: synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.92 | 6.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL120826 | — | — | 1 | 6.68 |
| CHEMBL121319 | — | — | 1 | 6.39 |
| CHEMBL333791 | — | — | 1 | 6.30 |
| CHEMBL121264 | — | — | 1 | 6.29 |
| CHEMBL121947 | — | — | 1 | 6.03 |
| CHEMBL120939 | — | — | 1 | 5.80 |
| CHEMBL122704 | — | — | 1 | 5.51 |
| CHEMBL7488 | — | — | 1 | 5.34 |
| CHEMBL22 | TRIMETHOPRIM | 4.0 | 1 | 4.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL120826 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL121319 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL333791 | — | IC50 | = | 502.0 | nM | 6.30 |
| CHEMBL121264 | — | IC50 | = | 517.0 | nM | 6.29 |
| CHEMBL121947 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL120939 | — | IC50 | = | 1570.0 | nM | 5.80 |
| CHEMBL122704 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL7488 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL22 | TRIMETHOPRIM | IC50 | = | 12000.0 | nM | 4.92 |