Assay Detail
Binding
CHEMBL665277
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Inhibitory activity against Cyclin D1-cyclin-dependent kinase 4 in enzymatic assay by measuring phosphorylation of Rb21
64
Total Activities
64
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Cyclin-dependent kinase 4/cyclin D1 (CHEMBL1907601) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 64 | 7.61 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL307150 | — | — | 1 | 8.70 |
| CHEMBL306856 | — | — | 1 | 8.40 |
| CHEMBL312292 | — | — | 1 | 8.30 |
| CHEMBL73764 | — | — | 1 | 8.30 |
| CHEMBL306611 | — | — | 1 | 8.22 |
| CHEMBL308541 | — | — | 1 | 8.22 |
| CHEMBL73485 | — | — | 1 | 8.15 |
| CHEMBL75368 | — | — | 1 | 8.10 |
| CHEMBL76499 | — | — | 1 | 8.05 |
| CHEMBL308099 | — | — | 1 | 8.05 |
| CHEMBL76326 | — | — | 1 | 8.00 |
| CHEMBL441258 | — | — | 1 | 8.00 |
| CHEMBL307630 | — | — | 1 | 7.96 |
| CHEMBL76390 | — | — | 1 | 7.96 |
| CHEMBL73832 | — | — | 1 | 7.96 |
| CHEMBL306748 | — | — | 1 | 7.92 |
| CHEMBL73343 | — | — | 1 | 7.92 |
| CHEMBL306501 | — | — | 1 | 7.89 |
| CHEMBL72808 | — | — | 1 | 7.89 |
| CHEMBL76464 | — | — | 1 | 7.85 |
| CHEMBL306047 | — | — | 1 | 7.82 |
| CHEMBL430606 | — | — | 1 | 7.82 |
| CHEMBL72607 | — | — | 1 | 7.80 |
| CHEMBL74637 | — | — | 1 | 7.77 |
| CHEMBL74883 | — | — | 1 | 7.75 |
| CHEMBL306114 | — | — | 1 | 7.75 |
| CHEMBL307007 | — | — | 1 | 7.72 |
| CHEMBL307152 | — | — | 1 | 7.72 |
| CHEMBL76337 | — | — | 1 | 7.72 |
| CHEMBL73718 | — | — | 1 | 7.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL307150 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL306856 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL73764 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL312292 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL306611 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL308541 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL73485 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL75368 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL76499 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL308099 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL76326 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL441258 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL76390 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL73832 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL307630 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL306748 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL73343 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL306501 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL72808 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL76464 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL306047 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL430606 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL72607 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL74637 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL306114 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL74883 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL307007 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL307152 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL76337 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL73718 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL72077 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL73751 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL308479 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL308116 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL308979 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL311851 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL75952 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL72076 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL310491 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL310260 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL75953 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL76332 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL73781 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL75610 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL73794 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL308252 | — | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL308994 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL73413 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL307219 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL72754 | — | IC50 | = | 42.0 | nM | 7.38 |