Assay Detail
Binding
CHEMBL665297
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytidine Deaminase Inhibition in human liver
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Liver |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 6.38 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311129 | — | — | 2 | 7.40 |
| CHEMBL2311128 | TETRAHYDROURIDINE | 2.0 | 1 | 7.00 |
| CHEMBL2367576 | — | — | 1 | 6.40 |
| CHEMBL608479 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311129 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL2311128 | TETRAHYDROURIDINE | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL2367576 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL2311129 | — | Ki | = | 900.0 | nM | 6.05 |
| CHEMBL608479 | — | Ki | = | 9000.0 | nM | 5.05 |