Assay Detail
Binding
CHEMBL665300
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Cytidine Deaminase Inhibition in mouse Kidney
6
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Synthesis of 1,3-diazepin-2-one nucleosides as transition-state inhibitors of cytidine deaminase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.23 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2311129 | — | — | 2 | 7.70 |
| CHEMBL2311128 | TETRAHYDROURIDINE | 2.0 | 1 | 6.66 |
| CHEMBL2367576 | — | — | 1 | 6.52 |
| CHEMBL608656 | — | — | 1 | 5.40 |
| CHEMBL608479 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2311129 | — | Ki | = | 20.0 | nM | 7.70 |
| CHEMBL2311128 | TETRAHYDROURIDINE | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL2367576 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL2311129 | — | Ki | = | 400.0 | nM | 6.40 |
| CHEMBL608656 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL608479 | — | Ki | = | 20000.0 | nM | 4.70 |